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KMID : 1149220050130010035
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Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 1 p.35 ~ p.48
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Effect of the neuroprotetion and anti-Alzheimer’s disease in CT99-induced PC12 cells by Gakamgobonhwan water extract
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Ahn Dae-Gwang
Lee So-Yeon
Yoon Hyeon-Deok
Shin Wo-Cheol
Park Chang-Gook
Park Chi-Sang
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. It has been widely believed that Aβ peptide devided from APP causes apoptotic neurotoxicity in brain. However, recent evidence suggests that n99 may be an important factor causing neurotoxicity in AD. Mouse PC12 cells expressed with n99 exhibited remarkable apoptotic cell damage. We invesgated the protective effects of Gagamgobonhwan water extract(GKG). Findings from our experiments have shown that GKG inhibits the activities of CT99, which has neurotoxicities and apoptotic activities in cell line. In addition, treatment of GKG(75 ㎍/ml 24 hours) partially prevented CT99-induced cytotoxicity in PC12 cells. As the result of this study, in GKG group the apoptosis in the nervous system was inhibited, the repair against the degerneration of PC12 cells by CT99 expression is promoted. Taken together, GKG exhibited inhibition of CT99-induced apoptotic cell death. GKG may be beneficial for the treatment of AD.
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KEYWORD
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Sodium Cyanide, Gakamgobonhwan, Anti-Dementia, CT99, PC12 cells, anti-Alzheimer’s disease
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